Research

Peer-reviewed Science Research Publications:

1.  Be N, Lamichhane G, Grosset J, Tyagi S, Cheng Q, Kim KS, Bishai WR, Jain SK. Murine model to study Invasion and Survival of Mycobacterium tuberculosis in the Central Nervous System. J Infect Dis. 2008 Nov 15;198(10):1520-8 [Cover article].

2.  Vidal C, Hewitt J, Davis S, Younes L, Jain S, Jedynak B. Template Registration with missing parts: Application to the Segmentation of Tuberculosis infected lungs. Proc IEEE Int Symp Biomed Imaging. 2009 Jun-Jul;2009:718-721.

3.  Davis SL, Be NA, Lamichhane G, Nimmagadda S, Pomper MG, Bishai WR, Jain SK. Bacterial Thymidine Kinase as a Non-Invasive Imaging Reporter for Mycobacterium tuberculosis in Live Animals. PLoS ONE 2009 4(7): e6297. doi:10.1371/journal.pone.0006297.

4.  Davis SL, Nuermberger EL, Um P, Vidal C, Jedynak B, Pomper MG, Bishai WR, Jain SK. Noninvasive pulmonary [18F]-2-fluoro-deoxy-D-glucose positron emission tomography correlates with bactericidal activity of tuberculosis drug treatment. Antimicrob Agents Chemother. 2009 Nov;53(11):4879-84. doi: 10.1128/AAC.00789-09. Epub 2009 Sep 8.

5.     Dutta NK, Mehra S, Didier PJ, Roy CJ, Doyle LA, Alvarez X, Ratterree M, Be NA, Lamichhane G, Jain SK, Lacey MR, Lackner AA, Kaushal D. Genetic requirements for the survival of tubercle bacilli in primates. J Infect Dis. 2010 Jun 1;201(11):1743-52.

6.     Vidal C, Beggs D, Younes L, Jain SK, Jedynak B. Incorporating user input in template-based segmentation. Proc IEEE Int Symp Biomed Imaging. 2011 Mar-Apr;2011:1434-1437.

7.     Be NA, Klinkenberg LG, Bishai WR, Karakousis PK, Jain SK. Strain-dependent CNS dissemination in guinea pigs after Mycobacterium tuberculosis aerosol challenge. Tuberculosis (Edinb). 2011 Sep;91(5):386-9.

8.     Harper J, Skerry C, Davis SL, Tasneen R, Weir W, Kramnik I, Bishai WR, Pomper MG, Nuermberger EL, Jain SK. Mouse model of necrotic TB granulomas develops hypoxic lesions. J Infect Dis. 2012 Feb;205(4):595-602.

9.  Be NA, Bishai WR, Jain SK. Role of Mycobacterium tuberculosis pknD in the Pathogenesis of Central Nervous System Tuberculosis. BMC Microbiol. 2012, 12:7.

10.  Skerry C, Harper J, Weir M, Bishai WR, Jain SK. Adjunctive TNF inhibition with standard treatment enhances bacterial clearance in a murine model of necrotic TB granulomas. PLoS One. 2012; 7(6):e39680. doi: 10.1371/journal.pone.0039680. Epub 2012 Jun 27.

11.  Weinstein EA, Liu L, Ordonez AA, Wang H, Hooker JM, Tonge PJ, Jain SK. Noninvasive Determination of 2-[18F]-Fluoroisonicotinicacid hydrazide Pharmacokinetics by Positron Emission Tomography in Mycobacterium tuberculosis Infected Mice. Antimicrob Agents Chemother. 2012 Sep 24.

12.  Skerry C, Pokkali S, Pinn M, Be NA, Harper J, Karakousis PC, Jain SK. Vaccination with recombinant Mycobacterium tuberculosis PknD confers protection against bacterial dissemination to the brain in guinea pigs. PLoS One. 2013; 8(6): e66310. doi:10.1371/journal.pone.0066310.

13.  Bagci U, Foster B, Miller-Jaster K, Luna B, Dey B, Bishai WR, Jonsson CB, Jain S, Mollura DJ. A computational pipeline for quantification of pulmonary infections in small animal models using serial PET-CT imaging. EJNMMI Res. 2013 Jul 23;3(1):55.

14.  Xu Z, Bagci U, Kubler A, Luna B, Jain S, Bishai WR, Mollura, DJ. Computer-Aided Detection and Quantification of Cavitary Tuberculosis from CT Scans. Med Phys. 2013 Nov;40(11):113701. doi: 10.1118/1.4824979.

15.  Foster B, Bagci U, Zu Z, Dey B, Luna B, Bishai W, Jain S, Mollura DJ. Segmentation of PET images for Computer-aided functional quantification of Tuberculosis in Small Animal Models. IEEE Trans Biomed Eng. 2013 Nov

16.  Foss CA, Harper JS, Wang H, Pomper MG, Jain SK. Non-Invasive Molecular Imaging of Tuberculosis-Associated Inflammation with Radioiodinated DPA-713. J Infect Dis. 2013 Dec;208(12):2067-74. [Cover article].

17.  Jain SK, Ordonez A, Gupte N, Kinikar A, Thakar M, Mave V, Jubulis J, Hatolkar S, Lalvani A, Kagal A, Gupta A, Bharadwaj R. Pediatric Tuberculosis in Young Children in India: A Prospective Study. Biomed Res Int. 2013:783698. doi: 10.1155/2013/783698. Epub 2013 Dec 10.

18.  Murawski AM, Gurbani S, Harper JS, Younes L, Jain SK, Jedynak B. Imaging the Evolution of Reactivation Pulmonary Tuberculosis in Mice Using 18F-FDG PET. J Nucl Med. 2014 Oct;55(10):1726-9.

19.  Luna B, Kubler A, Larsson C, Foster B, Bagci U, Mollura DJ, Jain S, Bishai WR. In vivo Prediction of Tuberculosis Cavity Formation in Rabbits. J Infect Dis. 2015 Feb 1;211(3):481-5.

20.  Ziyue Xu, Bagci U, Jonsson C, Jain S, Mollura DJ. Accurate and Efficient Separation of Left and Right Lungs from 3D CT Scans: a Generic Hysteresis Approach. Conf Proc IEEE Eng Med Biol Soc. 2014 Aug;2014:6036-9. doi: 10.1109/EMBC.2014.6945005

21.  Kübler A, Luna B, Larsson C, Ammerman NC, Andrade BB, Orandle M, Bock KW, Xu Z, Bagci U, Molura DJ, Marshall J, Burns J, Winglee K, Ahidjo BA, Cheung LS, Klunk M, Jain SK, Kumar NP, Babu S, Sher A, Friedland JS, Elkington PT, Bishai WR. Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation. J Pathol. 2015 Feb;235(3):431-44.

22.  Weinstein EA, Ordonez AA, DeMarco VP, Murawski AM, Pokkali S, MacDonald EM, Klunk M, Mease RC, Pomper MG, Jain SK. Imaging Enterobacteriaceae infection in vivo with 18F-fluorodeoxysorbitol positron emission tomography. Sci Transl Med. 2014 Oct 22; 6(259):259ra146. doi: 10.1126/scitranslmed.3009815. [Cover article and Accompanying Editorial].

23.  Ordonez AA, Pokkali S, DeMarco VP, Klunk M, Mease RC, Foss CA, Pomper MG, Jain SK. Radioiodo-DPA-713 Imaging Correlates with Bactericidal Activity of Tuberculosis Treatments in Mice. Antimicrob Agents Chemother. 2015 Jan;59(1):642-9. doi: 10.1128/AAC.04180-14. Epub 2014 Nov 17.

24.  Ordonez AA, DeMarco VP, Klunk MH, Pokkali S, Jain SK. Imaging Chronic Tuberculous Lesions using Sodium [18F]Fluoride Positron Emission Tomography in Mice. Mol Imaging Biol. 2015 Oct;17(5):609-14.

25.  Xu Z, Bagci U, Mansoor A, Marek GK, Luna B, Kubler A, Dey B, Foster B, Papadakis GZ, Camp JV, Jonsson CB, Bishai WR, Jain S, Udupa JK, Mollura DJ. Computer-aided pulmonary image analysis in small animal models. Med Phys. 2015 Jul;42(7):3896.

26.  DeMarco VP, Ordonez AA, Klunk M, Prideaux B, Wang H, Zhuo Z, Tonge PJ, Dannals RF, Holt DP, Lee CK, Weinstein EA, Dartois V, Dooley KE, Jain SK. Determination of 11C-Rifampin Pharmacokinetics within Mycobacterium tuberculosis-Infected Mice Using Dynamic Positron Emission Tomography Bioimaging. Antimicrob Agents Chemother. 2015 Sep;59(9):5768-74.

27.  Salazar-Austin N, Ordonez AA, Hsu A, Benson JE, Mahesh M, Menachery E, Razeq JH, Salfinger M, Starke JR, Milstone AM, Parrish N, Nuermberger EL, Jain SK. Extensively Drug-Resistant Tuberculosis in a Young Child after Travel to India. Lancet Infect Dis. 2015;15:1485-91.

28.  Ordonez AA, Tasneen R, Pokkali S, Xu Z, Converse PJ, Klunk MH, Mollura DJ, Nuermberger EL, Jain SK. Mouse Model of Pulmonary Cavitary Tuberculosis and Expression of Matrix Metalloproteinase-9. Dis Model Mech. 2016 Jul 1;9(7):779-88.

29.  Ahidjo BA, Maiga MC, Ihms EA, Maiga M, Ordonez AA, Cheung LS, Beck S, Andrade BB, Jain SK, Bishai WR. The antifibrotic drug pirfenidone promotes pulmonary cavitation and drug resistance in a mouse model of chronic tuberculosis. JCI Insight. 2016 Sep 8;1(14):e86017.

30.  Lentz CS, Ordonez AA, Kasperkiewicz P, Greca FL, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M. Design of selective substrates and activity-based probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis. ACS Infect Dis. 2016 Nov 11;2(11):807-815.

31.  Ashbaugh AG, Jiang X, Zheng J, Tsai AS, Kim WS, Thompson JM, Miller RJ, Shahbazian JH, Wang Y, Ordonez AA, Chang YS, Jain SK, Jones LC, Sterling RS, Mao HQ, Miller LS. Polymeric nanofiber coating with tunable combinatorial antibiotic delivery prevents biofilm-associated infection in vivo. Proc Natl Acad Sci U S A. 2016 Oct 24. pii: 201613722.

32.  Tucker EW, Pokkali S, Zhang Z, DeMarco VP, Klunk M, Smith E, Ordonez AA, Penet M, Bhujwalla Z, Jain SK, Kannan S. Microglia activation in a pediatric rabbit model of Tuberculosis Meningitis. Dis Model Mech. 2016 Dec 1;9(12):1497-1506.

33.  Ordonez AA, Weinstein EA, Bambarger LE, Saini V, Chang YS, DeMarco VP, Klunk M, Urbanowski ME, Moulton KL, Murawski AM, Pokkali S, Kalinda AS, Jain SK. A Systematic Approach for Developing Bacteria-Specific Imaging Tracers. J Nucl Med. 2017 Jan;58(1):144-150.

34.  Zhang Z, Ordonez AA, Smith-Jones P, Wang H, Gogarty KR, Daryaee F, Bambarger LE, Chang YS, Jain SK, Tonge PJ. The Biodistribution of 5-[18F]fluoropyrazinamide in Mycobacterium tuberculosis-infected Mice determined by Positron Emission Tomography. PLoS One. 2017 Feb 2;12(2):e0170871. doi: 10.1371/journal.pone.0170871.

35.  Shaikh N, Gupte A, Dharmshale S, Pokkali S, Thakar M, Upadhye VJ, Ordonez AA, Kinikar A, Gupte N, Mave V, Kagal A, Gupta A, Lalvani A, Paranjpe R, Bharadwaj R, Jain SK. Novel interferon γ assays for diagnosing tuberculosis in young children in India. Int J Tuberc Lung Dis. 2017 Apr 1;21(4):412-419.

36.  Thompson JM, Saini V, Ashbaugh AG, Miller RJ, Ordonez AA, Ortines RV, Wang Y, Sterling RS, Jain SK, Miller LS. Oral-Only Linezolid-Rifampin is Highly Effective Compared with Other Antibiotics for Prosthetic Joint Infection. Study of a Mouse Model. J Bone Joint Surg Am. 2017 Apr 19;99(8):656-665.

37.  Sarabia-Estrada R, Ruiz-Valls A, Shah SR, Ahmed AK, Ordoñez A, Rodriguez F, Guerrero-Cazares H, Jimenez-Estrada I, Velarde E, Tyler B, Li Y, Phillips NA, Goodwin CR, Petteys RJ, Jain SK, Gallia GL, Gokaslan ZL, Quinones-Hinojosa A, Sciubba DM. Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model. J Neurosurg Spine. 2017 Jun 9:1-12.

38.  Javadi MS, Ordonez AA, Jain SK. Re: Increased 18F-2-Fluorodeoxysorbitol (18F-FDS) Activity in a Pituitary Spindle Cell Carcinoma. Clin Nucl Med. 2017 Aug;42(8):649.

39.  Salazar-Austin N, Akinboyo I, Jain SK. Successful Cure of Extensively Drug‐Resistant Pulmonary Tuberculosis in a Young Child. Lancet Infect Dis. 2017 Sep;17(9):898-899.

40.  Seth R, Akinboyo I, Chhabra A, Qaiyum Y, Shet A, Gupte N, Jain AK, Jain SK. Mobile-Phone Incentives for Childhood Immunizations in Rural India. Pediatrics. 2018 Apr;141(4).

41.  Rifat D, Prideaux B, Savic RM, Urbanowski ME, Parsons TL, Luna B, Marzinke MA, Ordonez AA, DeMarco VP, Jain SK, Dartois V, Bishai WR, Dooley KE. Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data. Sci Transl Med. 2018 Apr 4; 10(435): eaai7786. DOI: 10.1126/scitranslmed.aai7786259ra146.

42.  Foss CA, Plyku D, Ordonez AA, Sanchez-Bautista J, Rosenthal HB, Minn I, Lodge MA, Pomper MG, Sgouros G, Jain SK. Biodistribution and Radiation Dosimetry of 124I-iodo-DPA-713, a PET Radiotracer for Macrophage-Associated Inflammation. J Nucl Med. 2018 Apr 26. pii: jnumed.117.207431. doi: 10.2967/jnumed.117.207431.

43.  Xu Z, Gao M, Papadakis GZ, Luna B, Jain S, Mollura DJ, Bagci U. Joint Solution for PET Image Segmentation, Denoising, and Partial Volume Correction. Med Image Anal. 2018 May;46:229-243.

44.  Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM. [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism. ACS Infect Dis. 2018 May 8. doi: 10.1021/acsinfecdis.8b00061.

45.  Ordonez AA, Pokkali S, Kim S, Carr B, Klunk MH, Tong L, Saini V, Chang YS, McKevitt M, Smith V, Gossage DL, Jain SK. Adjunct antibody administration with standard treatment reduces relapse rates in a murine tuberculosis model of necrotic granulomas. PLoS One. 2018 May 14;13(5): e0197474. doi: 10.1371/journal.pone.0197474.

46.  Zhang Z, Ordonez AA, Wang H, Li Y, Gogarty KR, Weinstein EA, Daryaee F, Merino J, Yoon GE, Kalinda AS, Mease RC, Iuliano JN, Smith-Jones PM, Jain SK, Tonge PJ. Positron Emission Tomography Imaging with 2-[18F]F-p-aminobenzoic Acid detects Staphylococcus aureus Infections and Monitors Drug Response. ACS Infect Dis. 2018 Aug 17. doi: 10.1021/acsinfecdis.8b00182.

47.  Tucker EW, Guglieri-Lopez B, Ordonez AA, Ritchie B, Klunk MH, Sharma R, Chang YS, Sanchez-Bautista J, Frey S, Lodge MA, Rowe SP, Holt DP, Gobburu J, Peloquin CA, Mathews WB, Dannals RF, Pardo CA, Kannan S, Ivaturi V, Jain SK. Noninvasive 11C-Rifampin Positron Emission Tomography Reveals Drug Biodistribution in Tuberculous Meningitis. Sci Transl Med. 2018 Dec 5; 10(470): eaau0965. DOI: 10.1126/scitranslmed.aau0965

48.  Holt DP, Kalinda AS, Bambarger LE, Jain SK, Dannals RF. Radiosynthesis and Validation of [Carboxy-11C]4-Aminobenzoic acid ([11C]PABA), A PET Radiotracer for Imaging Bacterial Infections. J Labelled Comp Radiopharm. 2019 Jan;62(1):28-33. doi: 10.1002/jlcr.3674.

49.  Ordonez AA, Pokkali S, Sanchez-Bautista J, Klunk MH, Urbanowski ME, Kübler A, Bishai WR, Elkington PT, Jain SK. Matrix Metalloproteinase Inhibition in a Murine Model of Cavitary Tuberculosis Paradoxically Worsens Pathology. J Infect Dis. 2019 Feb 15;219(4):633-6. [Cover article].

50.  Sanchez-Bautista J, Foss CA, Ordonez AA, Klunk MH, Jain SK. Imaging Pulmonary Foreign Body Reaction using [125I]iodo-DPA-713 SPECT/CT in Mice. Mol Imaging Biol. 2019 Apr;21(2):228-231.

51.  Werner R, Ordonez AA, Sanchez-Bautista J, Marcus C, Lapa C, Rowe SP, Pomper MG, Leal JP, Lodge MA, Javadi MS, Jain SK, Higuchi T. Novel functional renal PET imaging with 18F-FDS in human subjects. Clin Nucl Med. 2019 May;44(5):410-411.

52.  Foss CA, Kulik L, Ordonez AA, Jain SK, Holers VM, Thurman JM, Pomper MG. SPECT-CT Imaging of Mycobacterium tuberculosis Infection with [125I]anti-C3d mAb. Mol Imaging Biol. 2019 Jun;21(3):473-481.

53.  Saini V, Ammerman NC, Chang YS, Tasneen R, Chaisson RE, Jain SK, Nuermberger EL, Grosset JH. Treatment-shortening effect of a novel regimen combining high-dose rifapentine and clofazimine in pathologically distinct mouse models of tuberculosis. Antimicrob Agents Chemother. 2019 Apr 1. pii: AAC.00388-19. doi: 10.1128/AAC.00388-19.

54.  Ordonez AA, Carroll LS, Abhishek S, Mota F, Ruiz-Bedoya CA, Klunk MH, Singh AK, Freundlich JS, Mease RC, Jain SK. Radiosynthesis and PET Bioimaging of 76Br-Bedaquiline in a Murine Model of Tuberculosis. ACS Infect Dis. 2019 Dec 13;5(12):1996-2002. doi: 10.1021/acsinfecdis.9b00207.

55.  Tucker EW, Pieterse L, Zimmerman MD, Udwadia ZF, Peloquin CA, Gler MA, Ganatra S, Tornheim J, Chawla P, Caoilli J, Ritchie B, Jain SK, Dartois V, Dooley KE. Delamanid Central Nervous System Pharmacokinetics in Tuberculous Meningitis in Rabbits and Humans. Antimicrob Agents Chemother. 2019 Aug 5. pii: AAC.00913-19. doi: 10.1128/AAC.00913-19.

56.  Ordonez AA, Wang H, Magombedze G, Ruiz-Bedoya C, Srivastava S, Chen A, Tucker EW, Urbanowski ME, Pieterse L, Cardozo-Ojeda E, Lodge MA, Shah MR, Holt DP, Mathews WB, Dannals RF, Gobburu J, Peloquin CA, Rowe SP, Gumbo T, Ivaturi V, Jain SK. Dynamic Imaging in Tuberculosis Patients Reveals Heterogeneous Drug Exposures in Pulmonary Lesions. Nat Med. 2020 (in press).

57. Mota F, Jadhav R, Ruiz-Bedoya CA, Ordonez AA, Klunk MH, Freundlich JS*, Jain SK*. Radiosynthesis and Biodistribution of 18F-Linezolid in Mycobacterium tuberculosis-infected Mice using PET. ACS Infect Dis. 2020 Apr 9. doi: 10.1021/acsinfecdis.9b00473.*co-corresponding authors.

58. Gordon O, Miller RJ, Thompson JM, Ordonez AA, Klunk MH, Dikeman DA, Joycs DP, Ruiz-Bedoya CA, Miller LM, Jain SK. Rabbit model of Staphylococcus aureus implant-associated spinal infection. Dis Model Mech. 2020 Jul 28;13(7):dmm045385. doi: 10.1242/dmm.045385.

59. Bhattacharya B, Xiao S, Chatterjee S, Urbanowski ME, Ordonez AA, Ihms EA, Agrahari G, Lun S, Berland R, Pichugin A, Gao Y, John H. Connor JH, Ivanov AR, Yan B, Kobzik L, Koo B, Jain SK, Bishai WR, Kramnik I. The integrated stress response mediates necrosis in murine Mycobacterium tuberculosis granulomas. J Clin Invest. 2021 Feb 1;131(3):e130319. doi: 10.1172/JCI130319

60. Ordonez AA, Tucker EW, Anderson CJ, Carter CL, Ganatra S, Kaushal D, Kramnik I, Lin PL, Madigan CA, Mendez S, Rao J, Savic RM, Tobin DM, Walzl G, Wilkinson RJ, Lacourciere KA, Via LE, Jain SK. Visualizing the Dynamics of Tuberculosis Pathology using Molecular Imaging. J Clin Invest. 2021;131(5):e145107. https://doi.org/10.1172/JCI145107.

61. Ordonez AA, Wintaco LM, Mota F, Restrepo AF, Ruiz-Bedoya CA, Reyes CF, Uribe LG, Abhishek S, D’Alessio FR, Holt DP, Dannals RF, Rowe SP, Castillo VR, Pomper MG, Granados U, Jain SK. Imaging Enterobacterales infections in patients using pathogen-specific positron emission tomography. Sci Transl Med. 2021 Apr 14;13(589):eabe9805. doi: 10.1126/scitranslmed.abe9805.

62. Babin B, Fernandez-Cuervo G, Sheng J, Green O, Ordonez AA, Turner M, Keller L, Jain SK, Shabat D, Bogyo M. A chemiluminescent protease probe for rapid, sensitive, and inexpensive detection of live Mycobacterium tuberculosis. ACS Cent Sci. 2021 May 26; 7(5): 803–814.

63. Pirovano G, Ordonez AA, Jain SK, Reiner T, Carroll LS, Pillarsetty NVK. Rapid detection of SARS-Cov-2 using a radiolabeled antibody. Nucl Med Biol. 2021;98-99:69-75. doi: 10.1016/j.nucmedbio.2021.05.002. Epub 2021 May 25.

64. Dhakal S, Ruiz‐Bedoya C, Zhou R, Creisher P, Villano J, Littlefield K, Castillo J, Marinho P, Jedlicka A, Ordonez A, Bahr M, Majewska N, Betenbaugh M, Flavahan K, Mueller A, Looney M, Quijada D, Mota F, Beck S, Brockhurst J, Braxton A, Castell N, Stover M, D'Alessio F, Pate KM, Karakousis P, Mankowski J*, Pekosz A*, Jain SK*, Klein S*. Sex differences in lung imaging and SARS‐CoV‐2 antibody responses in a COVID‐19 golden Syrian hamster model. mBio. 2021 Jul 13:e0097421. doi: 10.1128/mBio.00974-21. *cocorresponding authors

65. Mota F, De Jesus P, Jain SK. Kit-based synthesis of 2-deoxy-2-[ 18F]-fluoro-ᴅ-sorbitol for bacterial imaging. Nat Protoc. 2021 Nov;16(11):5274-5286. doi: 10.1038/s41596-021-00613-2.

66. Gordon O, Lee DE, Liu B, Langevin B, Ordonez AA, Dikeman DA, Shafiq B, Thompson JM, Sponseller PD, Flavahan K, Lodge MA, Rowe SP, Dannals RF, Ruiz-Bedoya CA, Read TD, Peloquin CA, Archer NK, Miller LS, Davis KM, Gobburu J, Jain SK. Dynamic PET-facilitated Modeling and High-dose Rifampin Regimens for Staphylococcus aureus Orthopedic Implant-Associated Infections. Sci Transl Med. 2021 Dec 1;13(622):eabl6851. doi: 10.1126/scitranslmed.abl6851.

67. Ordonez AA, Parker MFL, Miller RJ, Plyku D, Ruiz-Bedoya CA, Tucker EW, Luu JM, Dikeman DA, Lesniak WG, Holt DP, Dannals RF, Miller LS, Rowe SP, Wilson DM, Jain SK. 11C-para-Aminobenzoic acid PET imaging of S. aureus and MRSA infection in preclinical models and human subjects. JCI Insight. 2022 Jan 11;7(1):e154117. doi: 10.1172/jci.insight.154117.

68. Gordon O, Brosnan MK, Yoon S, Jung D, Littlefield K, Ganesan A, Caputo CA, Li M, Morgenlander WR, Henson S, Ordonez AA, De Jesus P, Tucker EW, Akindele NP, Ma Z, Wilson J, Ruiz-Bedoya CA, M. Younger EM, Bloch EM, Shoham S, Sullivan D, Tobian AAR, Cooke KR, Larman B, Gobburu JVS, Casadevall A, Pekosz A, Lederman H, Klein SL, Jain SK. Pharmacokinetics of High-titer Anti-SARS-CoV2 Human Convalescent Plasma in High-risk Children. JCI Insight. 2022 Jan 25;7(2):e151518. doi: 10.1172/jci.insight.151518.

69. Ruiz-Bedoya CA, Mota F, Ordonez AA, Foss CA, Singh AK, Praharaj M, Mahmud FJ, Ghayoor A, Flavahan K, De Jesus P, Bahr M, Dhakal S, Zhou R, Solis CV, Mulka KR, Bishai WR, Pekosz A, Mankowski JL, Villano J, Klein SL*, Jain SK*. 124I-Iodo-DPA-713 Positron Emission Tomography in a Hamster Model of SARS-CoV-2 Infection. Mol Imaging Biol. 2022 Feb;24(1):135-143. doi: 10.1007/s11307-021-01638-5. Epub 2021 Aug 23. *co-corresponding authors

70. Ruiz-Bedoya CA, Mota F, Tucker EW, Mahmud FJ, Reyes-Mantilla MI, Erice C, Bahr M, Flavahan K, de Jesus P, Kim J, Foss CA, Peloquin CA, Hammoud DA, Ordonez AA, Pardo CA, Jain SK. High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis. J Clin Invest. 2022 Mar 15;132(6):e155851. doi: 10.1172/JCI155851.

71. Ordonez AA, Bullen CK, Villabona-Rueda AF, Thompson EA, Turner ML, Merino VF, Yan Y, Kim J, Davis SL, Komm O, Powell JD, D'Alessio FR, Yolken RH, Jain SK, Jones-Brando L Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice. Commun Biol 5, 242 (2022). https://doi.org/10.1038/s42003-022-03189-z

72. Mota F, Ruiz-Bedoya CA, Tucker EW, Holt DP, De Jesus P, Lodge MA, et al. Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies. Vol. 13, Nature Communications. Springer Science and Business Media LLC; 2022. http://dx.doi.org/10.1038/s41467-022-35730-3

73. Merino VF, Yan Y, Ordonez AA, Bullen CK, Lee A, Saeki H, et al. Nucleolin mediates SARS-CoV-2 replication and viral-induced apoptosis of host cells. Vol. 211, Antiviral Research. Elsevier BV; 2023. p. 105550. http://dx.doi.org/10.1016/j.antiviral.2023.105550

74. Krug S, Prasad P, Xiao S, Lun S, Ruiz-Bedoya CA, Klunk M, et al. Adjunctive Integrated Stress Response Inhibition Accelerates Tuberculosis Clearance in Mice. Philips J, editor. Vol. 14, mBio. American Society for Microbiology; 2023. http://dx.doi.org/10.1128/mbio.03496-22

75. Jacquot C, Gordon O, Noland D, Donowitz JR, Levy E, Jain S, et al. Multi‐institutional experience with COVID‐19 convalescent plasma in children. Vol. 63, Transfusion. Wiley; 2023. p. 918–24. http://dx.doi.org/10.1111/trf.17318

76. Ordonez AA, Saupe F, Kasper CA, Turner ML, Parveen S, Flavahan K, et al. Imaging Tumor-Targeting Bacteria Using 18F-Fluorodeoxysorbitol Positron Emission Tomography. Vol. 228, The Journal of Infectious Diseases. Oxford University Press (OUP); 2023. p. S291–6. http://dx.doi.org/10.1093/infdis/jiad077

77. Parker MFL, López-Álvarez M, Alanizi AA, Luu JM, Polvoy I, Sorlin AM, et al. Evaluating the Performance of Pathogen-Targeted Positron Emission Tomography Radiotracers in a Rat Model of Vertebral Discitis-Osteomyelitis. Vol. 228, The Journal of Infectious Diseases. Oxford University Press (OUP); 2023. p. S281–90. http://dx.doi.org/10.1093/infdis/jiad159

78. Singh AK, Wang R, Lombardo KA, Praharaj M, Bullen CK, Um P, et al. Intravenous BCG vaccination reduces SARS-CoV-2 severity and promotes extensive reprogramming of lung immune cells. Vol. 26, iScience. Elsevier BV; 2023. p. 107733. http://dx.doi.org/10.1016/j.isci.2023.107733

79. Tucker EW, Ruiz-Bedoya CA, Mota F, Erice C, Kim J, de Jesus P, Jahdav R, Bahr M, Flavahan K, Chen X, Peloquin CA, Freundlich JS, Jain SK. Linezolid does not improve bactericidal activity of rifampin-containing first-line regimens in animal models of TB meningitis. Int J Antimicrob Agents. 2023 Dec 5:107048. doi: 10.1016/j.ijantimicag.2023.107048. Epub ahead of print. PMID: 38061419.

Reviews and Editorials:

1.  Be N, Kim KS, Bishai WR, Jain SK. Pathogenesis of Central Nervous System Tuberculosis. Curr Mol Med. 2009 Mar;9(2):94-9.

2.  Everton KL, Mazal J, Mollura DJ, for RAD-AID Conference Writing Group*. White Paper Report of the 2011 RAD-AID Conference on International Radiology for Developing Countries: Integrating Multidisciplinary Strategies for Imaging Services in the Developing World. J Am Coll Radiol 2012;9:488-494.

3.  Pokkali S, Jain SK. Novel Vaccine Strategies against Tuberculosis: A Road Less Travelled. Expert Rev Vaccines. 2013 Dec;12(12):1373-5.

4.   Ordonez AA, Maiga M, Gupta S, Weinstein EA, Bishai WR, Jain SK. Novel Adjunctive Therapies for the Treatment of Tuberculosis. Curr Mol Med. 2014 Mar;14(3):385-95.

5. Johnson D, Via L, Kim P, Laddy D, Lau CY, Weinstein E, Jain SK. Nuclear Imaging: A Powerful Novel Approach for Tuberculosis. Nucl Med Biol. 2014 Nov-Dec;41(10):777-84.

6. Jain SK. The Promise of Molecular Imaging in the Study and Treatment of Infectious Diseases. Mol Imaging Biol. 2017 Jun;19(3):341-347.

7. Tucker EW, Jain SK, Mahesh M. Balancing the Risks of Radiation and Anesthesia in Pediatric Patients. J Am Coll Radiol. 2017 Jul 24. pii: S1546-1440(17)30694-4.

8. Ordonez AA, Jain SK. Pathogen-Specific Bacterial Imaging in Nuclear Medicine. Semin Nucl Med. 2018 Mar;48(2):182-194.

9.  Foss CA, Sanchez J, Jain SK. Imaging Macrophage-associated Inflammation. Semin Nucl Med. 2018 Mar;48(2):242-245.

10. Jain SK, Tobin DM, Tucker EW, Venketaraman V, Ordonez AA, Jayashankar L, Siddiqi OK, Hammoud DA, Prasadarao NV, Sandor M, Hafner R, Fabry Z on behalf of the NIH Tuberculous Meningitis Writing Group. Tuberculous meningitis: a roadmap for advancing basic and translational research. Nat Immunol. 2018 Jun;19(6):521-525. doi: 10.1038/s41590-018-0119-x.

11.  Rohlwink UK, Walker NF, Ordonez AA, Li YJ, Tucker EW, Elkington PT, Wilkinson RJ, Wilkinson KA. “Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis-A Review”. International Journal of Molecular Sciences. 2019;20(6).

12.  Ordonez AA, Sellmyer MA, Gowrishankar G, Ruiz-Bedoya CA, Tucker EW, Palestro CJ, Hammoud DA, Jain SK. Molecular imaging of bacterial infections: Overcoming the barriers to clinical translation. Sci Transl Med. 2019 Sep 4;11(508). pii: eaax8251. doi: 10.1126/scitranslmed.aax8251.

13.  Gordon O, Ruiz-Bedoya CA, Ordonez AA, Tucker EW, Jain SK. Molecular Imaging: A Novel Tool to Visualize Pathogenesis of Infections In Situ. MBio. 2019 Oct 29;10(5). pii: e00317-19. doi: 10.1128/mBio.00317-19.

14.  Ruiz-Bedoya CA, Gordon O, Mota F, Abhishek S, Tucker EW, Ordonez AA, Jain SK. Molecular Imaging of Diabetic Foot Infections: New Tools for Old Questions. Int J Mol Sci. 2019 20(23), 5984; https://doi.org/10.3390/ijms20235984.

15.  Filipa Mota, Camilo Ruiz-Bedoya, Elizabeth Tucker et al. Dynamic 18F-Pretomanid PET imaging reveals excellent brain penetration in animal models of TB meningitis and first-in-human studies, 06 September 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1999411/v1]

16.  Mota F, Jain SK. Flagging bacteria with radiolabeled D-amino acids. ACS Cent Sci. 2020 Feb 26;6(2):97- 99. doi: 10.1021/acscentsci.0c00096.

17. Urbanowski ME, Ordonez AA, Ruiz-Bedoya CA, Jain SK, Bishai WR. Cavitary tuberculosis: the gateway of disease transmission. Lancet Infect Dis. 2020 Jun;20(6):e117-e128. doi: 10.1016/S1473-3099(20)30148-1.

18. Toyama Y, Werner RA, Ruiz-Bedoya CA, Ordonez AA, Takase K, Lapa C, Jain SK, Pomper MG, Rowe SP, Higuchi T. Current and Future Perspectives on Functional Molecular Imaging in Nephro-Urology: Theranostics on the Horizon. Theranostics. 2021 Apr 7;11(12):6105-6119. doi: 10.7150/thno.58682.

19. Braxton AM, Creisher PS, Ruiz-Bedoya CA, Mulka KR, Dhakal S, Ordonez AA, Beck SE, Jain SK, Villano JS. Hamsters as a Model of Severe Acute Respiratory Syndrome Coronavirus-2. Comp Med. 2021 Sep 29. doi: 10.30802/AALAS-CM-21-000036.

20. Jain SK. New Approaches for Imaging Bacteria. Semin Nucl Med 53:138-141 (2022). https://doi.org/10.1053/j.semnuclmed.2022.12.002

21. Hammoud DA, Clifford Lane H, Jain SK. Molecular Imaging of Infections: Advancing the Search for the Hidden Enemy. Vol. 228, The Journal of Infectious Diseases. Oxford University Press (OUP); 2023. p. S233–6. http://dx.doi.org/10.1093/infdis/jiad079

22. Chen X, Gallagher F, Sellmyer MA, Ordonez AA, Kjaer A, Ohliger M, et al. Visualizing Bacterial Infections With Novel Targeted Molecular Imaging Approaches. Vol. 228, The Journal of Infectious Diseases. Oxford University Press (OUP); 2023. p. S249–58. http://dx.doi.org/10.1093/infdis/jiad078

23. Alberto S, Ordonez AA, Arjun C, Aulakh GK, Beziere N, Dadachova E, et al. The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection. Vol. 64, Journal of Nuclear Medicine. Society of Nuclear Medicine; 2023. p. 1676–82. http://dx.doi.org/10.2967/jnumed.123.265906