Buzz and news
December 2023 - Hot of the press: Linezolid does not improve bactericidal activity of rifampin-containing first-line regimens in animal models of TB meningitis. Learn more: https://doi.org/10.1016/j.ijantimicag.2023.107048
October 2023 - Next-generation molecular imaging affords unique opportunities to target and identify bacterial infections, enabling spatial characterization as well as noninvasive, temporal monitoring of the natural course of the disease and response to therapy. Learn more: https://doi.org/10.1093/infdis/jiad078
December 2022 - Hot off the press - Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies - https://doi.org/10.1038/s41467-022-35730-3
January 2022 - Hot off the press - We used a combination of Microbiology and Molecular Imaging approaches to assess the efficacy of a new regimen for TB meningitis, and monitor its impact on neuroinflammation and BBB integrity. Check our latest paper in JCI https://www.jci.org/articles/view/155851
January 2022 - Hot off the press - Trouble diagnosing MRSA prosthetic joint infections? Our work shows how bacteria-specific PET imaging can detect Staph infections in muscle, bone, and implants. Check out our latest paper in JCI insight: https://insight.jci.org/articles/view/154117
December 2021 - Down to the Bone: High-dose rifampin to shorten the duration of treatment for bone infection. Check our latest translational study in Science Translational Medicine: https://pubmed.ncbi.nlm.nih.gov/34851697/
December 2021 - Hot of the press! High-risk children may develop severe COVID, can convalescent plasma give them enough antibodies for protection? https://insight.jci.org/articles/view/151518#.Yaj8-tp0a6M.twitter
July 2021 -Hot off the press- Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model. MBio (https://journals.asm.org/doi/10.1128/mBio.00974-21)
April 2021 -Hot off the press- Imaging Enterobacterales infections in patients using pathogen-specific positron emission tomography. Science Translational Medicine (https://stm.sciencemag.org/content/13/589/eabe9805)
“Imaging Agent Spots and Distinguishes Dangerous Bacterial Infections”
Our lab
The major focus of Dr. Jain’s Lab is on pathogenesis of infections, with a special emphasis on bacteria and high-containment pathogens such as Mycobacterium tuberculosis (causative agent of tuberculosis) and recently SARS-CoV-2. We use small animal models and cutting-edge molecular imaging technologies to develop and test novel radiopharmaceutical imaging methods (CT, PET, SPECT, MRI) to study disease pathogenesis as well as to develop precision medicine tools for the diagnosis and monitoring of infections. We have the unique capacity to image animals infected with high-containment pathogens (up to biosafety level-3). Several novel tracers developed in our laboratory are now being tested in first-in-human studies.